Collaborative Innovation
Research Area
Science & Innovation
The Concept of Glucose Homeostasis
In Healthy Humans
Glucose concentrations for healthy individuals are maintained within a narrow range of 4-6.5mM --- glucose homeostasis, and regulated by various pathways. As the glucose sensor, glucokinase (GK) senses changes in glucose levels, which is essential for maintaining whole-body glucose homeostasis.
In Patients with Type 2 Diabetes
Impaired GK activity and function in T2D patients results in defects in glucose sensing, leading to disrupted glucose homeostasis.
Glucokinase Activator (GKA) Restores
A GKA can repair defective GK function and restore glucose homeostasis.
In Healthy Humans
Glucose concentrations for healthy individuals are maintained within a narrow range of 4-6.5mM --- glucose homeostasis, and regulated by various pathways. As the glucose sensor, glucokinase (GK) senses changes in glucose levels, which is essential for maintaining whole-body glucose homeostasis.
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